分类： 物理学 >> 核物理学 提交时间： 2023-05-31
摘要： The properties of exotic nuclei are the focus of the present research. Two-neutron halo structures of neutron-rich 17,19B were experimentally confirmed. We studied the formation mechanism of halo phenomena in 17, 19B using the complex momentum representation method applied to deformation and continuum coupling. By examining the evolution of the weakly bound and resonant levels near the Fermi surface, sd orbital reversals and certain prolate deformations were observed. In addition, by analyzing the evolution of the occupation probabilities and density distributions occupied by valence neutrons, we found that the ground state of 15B did not exhibit a halo, and the ground states of 17B and 19B exhibited halos at 0.620.7 and 0.320.7, respectively. The low-l components in the valence levels that are weakly bound or embedded in the continuous spectrum lead to halo formation.
分类： 生物学 >> 生物物理学 >> 细胞生物学 提交时间： 2016-05-15
Zhang, Dongdong
Zhang, Weimin
Li, Dan
Fu, Ming
Zhan, Qimin
Zhang, Dongdong
Zhang, Weimin
Li, Dan
Fu, Ming
Zhan, Qimin
Zhang, Dongdong
Chen, Runsheng
Zhan, Qimin
摘要： GADD45A is a TP53-regulated and DNA damage-inducible tumor suppressor protein, which regulates cell cycle arrest, apoptosis, and DNA repair, and inhibits tumor growth and angiogenesis. However, the function of GADD45A in autophagy remains unknown. In this report, we demonstrate that GADD45A plays an important role in regulating the process of autophagy. GADD45A is able to decrease LC3-II expression and numbers of autophagosomes in mouse tissues and different cancer cell lines. Using bafilomycin A(1) treatment, we have observed that GADD45A regulates autophagosome initiation. Likely, GADD45A inhibition of autophagy is through its influence on the interaction between BECN1 and PIK3C3. Immunoprecipitation and GST affinity isolation assays exhibit that GADD45A directly interacts with BECN1, and in turn dissociates the BECN1-PIK3C3 complex. Furthermore, we have mapped the 71 to 81 amino acids of the GADD45A protein that are necessary for the GADD45A interaction with BECN1. Knockdown of BECN1 can abolish autophagy alterations induced by GADD45A. Taken together, these findings provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1-PIK3C3 complex formation.
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